211 articles — showing all

A Moderate Group Difference, Not a Diagnostic Test: Appraising the Pooled Evidence on Urinary Kidney Injury Molecule-1 in Neonatal Acute Kidney Injury
Epidemiology & BiostatisticsMeta-analysis

A Moderate Group Difference, Not a Diagnostic Test: Appraising the Pooled Evidence on Urinary Kidney Injury Molecule-1 in Neonatal Acute Kidney Injury

Researchers combined 13 small studies of 552 newborns to ask whether a protein in a baby's urine, called kidney injury molecule-1, is raised when the kidneys have been injured. It was — but only moderately, and the studies disagreed a great deal, so the researchers rated their own confidence in the…

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A Patented Double-Lumen Tracheal Tube Delivers Surfactant Without a Detectable Penalty Against Thin-Catheter Instillation
Randomized Clinical TrialPharmacology

A Patented Double-Lumen Tracheal Tube Delivers Surfactant Without a Detectable Penalty Against Thin-Catheter Instillation

Premature babies often lack surfactant, a substance that keeps the tiny air sacs in the lungs from collapsing, so doctors give it as a medicine soon after birth. A study of 138 babies in six Chinese hospitals compared the usual method — a thin tube passed briefly into the windpipe — with a newly…

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Enteral Vitamin A and the Elusive Prevention of Bronchopulmonary Dysplasia
Meta-analysisNutrition & Metabolism

Enteral Vitamin A and the Elusive Prevention of Bronchopulmonary Dysplasia

Premature babies are often given vitamin A in the hope of protecting their fragile lungs from a chronic lung condition called bronchopulmonary dysplasia. A 2025 review combined five clinical trials involving 1,715 very premature babies and found that vitamin A given by mouth did not meaningfully…

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Physiological-Based Cord Clamping Does Not Improve Intact Survival in Very Preterm Infants, but Halves Anaemia-Related and Infectious Morbidity
Randomized Clinical TrialPhysiology

Physiological-Based Cord Clamping Does Not Improve Intact Survival in Very Preterm Infants, but Halves Anaemia-Related and Infectious Morbidity

A large European study has tested a gentler way to handle the umbilical cord at a very premature birth: instead of clamping the cord after a set number of seconds, doctors waited until the baby was breathing well and stable before clamping. This approach did not increase the number of babies who…

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Kidney–Brain Crosstalk in the Extremely Preterm Infant: Neonatal Acute Kidney Injury and Two-Year Neurodevelopmental Impairment
NeuroscienceEpidemiology & Biostatistics

Kidney–Brain Crosstalk in the Extremely Preterm Infant: Neonatal Acute Kidney Injury and Two-Year Neurodevelopmental Impairment

A large US study of 660 children who were born extremely prematurely found that those who had a sudden kidney problem in their first weeks of life were more likely, two years later, to have delays in thinking and learning. About 4 in 10 of these babies had such kidney injury, and after accounting…

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