53 articles in Respiratory

Predicting, Testing and Interpreting Extubation Failure in Very Preterm Infants: What Three Retrospective Cohorts Can and Cannot Tell Us
Epidemiology & BiostatisticsPhysiology

Predicting, Testing and Interpreting Extubation Failure in Very Preterm Infants: What Three Retrospective Cohorts Can and Cannot Tell Us

Premature babies on a breathing machine sometimes need their breathing tube put back in within days of it being removed. Three new studies looked at which babies are most likely to need this, whether a 3-minute breathing test works as well as a 10-minute one, and what it means afterwards. Being…

scientificclinicalfamily
Neurally Adjusted Ventilatory Assist After Congenital Diaphragmatic Hernia Repair: Lower Oxygenation Index at Lower Airway Pressures in a Small Randomised Crossover Trial
PhysiologyRandomized Clinical Trial

Neurally Adjusted Ventilatory Assist After Congenital Diaphragmatic Hernia Repair: Lower Oxygenation Index at Lower Airway Pressures in a Small Randomised Crossover Trial

After surgery for a congenital diaphragmatic hernia, most babies need a breathing machine while their small lungs recover; in a small London study, nine such babies each spent four hours on the usual setting and four hours on NAVA, a setting that follows the baby's own breathing signal. All nine…

scientificclinicalfamily
Can a Pleasant Odor Reduce Apnea of Prematurity in Infants on Nasal CPAP? Delivery, Dose and the Limits of Olfactory Stimulation
Randomized Clinical TrialPhysiology

Can a Pleasant Odor Reduce Apnea of Prematurity in Infants on Nasal CPAP? Delivery, Dose and the Limits of Olfactory Stimulation

Many babies born very early have short pauses in their breathing that can make their oxygen level and heart rate dip. Researchers in Zurich, Switzerland, tested whether a pleasant vanilla or strawberry smell placed inside the small mask that helps these babies breathe could reduce those episodes…

scientificclinicalfamily
Enteral Sildenafil in Severe Bronchopulmonary Dysplasia: What a Randomised Dose-Escalation Trial Can and Cannot Tell Us About Safety
PharmacologyRandomized Clinical Trial

Enteral Sildenafil in Severe Bronchopulmonary Dysplasia: What a Randomised Dose-Escalation Trial Can and Cannot Tell Us About Safety

Many very premature babies with long-term lung disease are given sildenafil, a medicine that relaxes the blood vessels in the lungs, even though it had not been tested in a large, carefully controlled trial in these babies. A careful study in 30 American hospitals has now found that, given by mouth…

scientificclinicalfamily
High-Frequency Oscillatory Ventilation in 2026: Lung Outcomes in Preterm Neonatal ARDS, Hemodynamics in Term PPHN, and the Validity of Ventilator-Derived CO2 Clearance
Randomized Clinical TrialPhysiology

High-Frequency Oscillatory Ventilation in 2026: Lung Outcomes in Preterm Neonatal ARDS, Hemodynamics in Term PPHN, and the Validity of Ventilator-Derived CO2 Clearance

Some sick newborns are helped to breathe by a machine that delivers tiny, very fast breaths, called high-frequency oscillation. Three new studies looked at it: one found a modest, uncertain hint of fewer lung problems in premature babies, one found both machine types improved circulation in…

scientificclinicalfamily
Oxygen Saturation Targets for Extremely Preterm Infants: From Pooled Relative Risks to Centre-Specific Trade-Offs and International Practice
Epidemiology & BiostatisticsHealth Systems & Policy

Oxygen Saturation Targets for Extremely Preterm Infants: From Pooled Relative Risks to Centre-Specific Trade-Offs and International Practice

Babies born very early often need extra oxygen, and their care team chooses a target range for how much oxygen their blood should carry. A slightly higher range saves some lives, but a few more babies then need treatment for an eye disease of prematurity. Two 2026 studies, a US computer model and a…

scientificclinicalfamily
Augmenting Nasal CPAP From the First Hours: Oscillation, Synchronised Breaths and the Limits of Two CPAP-Controlled Trials in Very Immature Infants
Randomized Clinical TrialPhysiology

Augmenting Nasal CPAP From the First Hours: Oscillation, Synchronised Breaths and the Limits of Two CPAP-Controlled Trials in Very Immature Infants

Many babies born very early need help to breathe, and doctors try to give that help through soft prongs in the nose rather than a tube in the windpipe. Two large studies from China found that adding either rapid, gentle air vibrations or extra timed "breaths" to the usual steady nasal pressure…

scientificclinicalfamily
Caffeine Before Less Invasive Surfactant Administration: What Two-Year Follow-Up of the CaLI Trial Does and Does Not Show
Randomized Clinical TrialNeuroscience

Caffeine Before Less Invasive Surfactant Administration: What Two-Year Follow-Up of the CaLI Trial Does and Does Not Show

Many babies born very early need a medicine called surfactant to help their lungs stay open. Researchers recently followed 147 of these babies for two years after they received that medicine in one of two different ways, to see whether the gentler method left them developing just as well — or even…

scientificclinicalfamily