20 articles in Cardiovascular

Three Drugs, Four Regimens, One Failure Rate: Comparative Effectiveness of Pharmacotherapy for the Patent Ductus Arteriosus in Extremely Preterm Infants
PharmacologyEpidemiology & Biostatistics

Three Drugs, Four Regimens, One Failure Rate: Comparative Effectiveness of Pharmacotherapy for the Patent Ductus Arteriosus in Extremely Preterm Infants

Many babies born very early have an open blood vessel near the heart, called a patent ductus arteriosus, and doctors sometimes give medicine to close it. A Canadian study of 1356 babies born before 29 weeks found that four common treatment options (three medicines, one of them given at two doses)…

scientificclinicalfamily
Choosing Which Duct to Treat: Shunt-Volume Selection and the Redesign of Early PDA Trials in Extremely Preterm Infants
Randomized Clinical TrialEpidemiology & Biostatistics

Choosing Which Duct to Treat: Shunt-Volume Selection and the Redesign of Early PDA Trials in Extremely Preterm Infants

Many babies born extremely early have an open blood vessel near the heart, and doctors have long debated whether medicine to close it early helps. A small 2026 trial in babies born before 26 weeks used repeated heart scans to give medicine only to babies with a large blood flow; it showed a bigger…

scientificclinicalfamily
Written Guidelines for Hemodynamically Significant Patent Ductus Arteriosus Show a Shared Framework With Variable Thresholds
Health Systems & PolicyEpidemiology & Biostatistics

Written Guidelines for Hemodynamically Significant Patent Ductus Arteriosus Show a Shared Framework With Variable Thresholds

Many babies born very early have a small blood vessel near the heart, called the ductus arteriosus, that has not closed yet. Doctors do not fully agree on when to treat it, so a research team asked children's hospital newborn units to share their written plans. The plans share a general approach…

scientificclinicalfamily
The False-Positive Problem in Prenatally Suspected Coarctation of the Aorta
Epidemiology & BiostatisticsPhysiology

The False-Positive Problem in Prenatally Suspected Coarctation of the Aorta

When a pregnancy scan suggests that a baby's main artery may be narrowed, families are often asked to prepare for heart surgery after birth. Yet in the largest series published in 2025 and 2026, about two thirds of those babies were born with a normal artery. Four new studies examine why this…

scientificclinicalfamily
Closing the Prenatal Detection Gap in Total Anomalous Pulmonary Venous Connection
Anatomy & EmbryologyEpidemiology & Biostatistics

Closing the Prenatal Detection Gap in Total Anomalous Pulmonary Venous Connection

Total anomalous pulmonary venous connection is a rare heart difference in which the veins carrying oxygen-rich blood back from the lungs join the wrong side of the heart. Surgery can repair it, but babies do far better when it is found on an ultrasound scan before birth — and it is one of the…

scientificclinicalfamily
The Week Before the Switch: Prenatal Prediction, Transitional Physiology and Preoperative Brain Injury in Transposition of the Great Arteries
PhysiologyNeuroscience

The Week Before the Switch: Prenatal Prediction, Transitional Physiology and Preoperative Brain Injury in Transposition of the Great Arteries

Transposition of the great arteries is a heart condition present at birth in which the two main arteries leaving the heart are connected the wrong way round. Surgery to correct it is now very successful, and most children grow up well. Four recent studies look at the part that is still hard: the…

scientificclinicalfamily
The Heart Around the Operation: Three 2026 Echocardiographic Cohorts Redraw the Perioperative Haemodynamic Map in Congenital Diaphragmatic Hernia
PathophysiologyPhysiology

The Heart Around the Operation: Three 2026 Echocardiographic Cohorts Redraw the Perioperative Haemodynamic Map in Congenital Diaphragmatic Hernia

When a baby is born with a hole in the diaphragm, the heart is squeezed as well as the lungs. Three studies published in 2026 used bedside ultrasound to follow how the heart works before and after the operation that closes the gap. Together they show that the right side of the heart recovers…

scientificclinicalfamily
A blood pressure problem that begins in the incubator and is still there at eighteen
Epidemiology & BiostatisticsPharmacology

A blood pressure problem that begins in the incubator and is still there at eighteen

Babies born too early sometimes develop high blood pressure in newborn intensive care, and doctors treat it — but no guideline says which medicine to use. Two 2025 studies fill in opposite ends of the picture: one found a large American hospital reached for the same drug about 61% of the time, out…

scientificclinicalfamily