19 articles in Gastroenterology & Bilirubin

From Pooled Accuracy to a Working Pathway: How Newborn Bilirubin Screening for Biliary Atresia Moved From Evidence to Algorithm
Epidemiology & BiostatisticsMeta-analysis

From Pooled Accuracy to a Working Pathway: How Newborn Bilirubin Screening for Biliary Atresia Moved From Evidence to Algorithm

Biliary atresia is a rare liver condition in newborns in which the tubes that carry bile out of the liver become blocked. Surgery works best when it happens in the first six weeks of life, but most babies are still diagnosed later than that. Two recent studies suggest that a simple blood test…

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Hydrocortisone, Combined Inotropes, and the Fragile Ileum: Re-Estimating the Pharmacologic Risk Profile for Spontaneous Intestinal Perforation
PharmacologyEpidemiology & Biostatistics

Hydrocortisone, Combined Inotropes, and the Fragile Ileum: Re-Estimating the Pharmacologic Risk Profile for Spontaneous Intestinal Perforation

Spontaneous intestinal perforation is a small hole that can open in the bowel of the tiniest premature babies, usually in the first week or two of life. A ten-year study of 858 extremely small newborns in Taiwan found that two common intensive-care treatments — a steroid called hydrocortisone, and…

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Adding Bifidobacterium to Phototherapy for Neonatal Jaundice: A Four-Arm Randomized Trial of Bilirubin Clearance and Gut Recovery
Randomized Clinical TrialMicrobiology

Adding Bifidobacterium to Phototherapy for Neonatal Jaundice: A Four-Arm Randomized Trial of Bilirubin Clearance and Gut Recovery

When a newborn develops jaundice — the yellow tint of the skin and eyes caused by a normal but temporary buildup of a substance called bilirubin — the usual treatment is phototherapy, a special blue light that helps the body clear it. A new study asked whether adding friendly gut bacteria, known as…

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A Test That Confirms Rather Than Predicts: Pooled Diagnostic Accuracy of the Direct Antiglobulin Test for Treatment-Requiring Neonatal Hyperbilirubinaemia
Meta-analysisEpidemiology & Biostatistics

A Test That Confirms Rather Than Predicts: Pooled Diagnostic Accuracy of the Direct Antiglobulin Test for Treatment-Requiring Neonatal Hyperbilirubinaemia

A common newborn blood test called the Coombs test looks for one specific cause of jaundice: antibodies from the mother attacking the baby's red blood cells. A large 2025 review pooling 28 studies and 20,935 newborns found that when the test is positive it does raise the odds a baby will need…

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A Breath Test to Right-Size Phototherapy: A Randomized Trial of ETCOc-Adjusted Risk Categorization in Neonatal Hyperbilirubinemia
Randomized Clinical TrialPathophysiology

A Breath Test to Right-Size Phototherapy: A Randomized Trial of ETCOc-Adjusted Risk Categorization in Neonatal Hyperbilirubinemia

A quick, painless breath test can help doctors safely give fewer newborns light treatment for jaundice. In a study of 2,500 babies, adding this test to the usual jaundice assessment lowered the share who needed the lights from about 22 out of 100 to about 19 out of 100 — without any increase in…

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