391 articles — showing all

From Maternal Antibody Titre to Neonatal Follow-Up: Assay-Specific Risk Prediction, Surveillance Fidelity and the Treated Course of Neonatal Graves' Disease
Epidemiology & BiostatisticsHealth Systems & Policy

From Maternal Antibody Titre to Neonatal Follow-Up: Assay-Specific Risk Prediction, Surveillance Fidelity and the Treated Course of Neonatal Graves' Disease

Mothers who have, or used to have, Graves' disease carry antibodies that can cross the placenta and briefly over-stimulate their baby's thyroid gland. Three 2026 studies show that a blood test in pregnancy can pick out the small number of babies at real risk, that hospitals do not always complete…

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Same Pathogen, Different Prescription: International Variation in Antimicrobial Duration and Sepsis Management for Infants Born Before 29 Weeks
Health Systems & PolicyEpidemiology & Biostatistics

Same Pathogen, Different Prescription: International Variation in Antimicrobial Duration and Sepsis Management for Infants Born Before 29 Weeks

When a very premature baby develops a blood infection, doctors around the world agree that antibiotics are needed, but they do not agree on how long to give them. A survey of 382 neonatal intensive care units in 12 neonatal networks found that the usual course ranged from under a week to three…

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Three Drugs, Four Regimens, One Failure Rate: Comparative Effectiveness of Pharmacotherapy for the Patent Ductus Arteriosus in Extremely Preterm Infants
PharmacologyEpidemiology & Biostatistics

Three Drugs, Four Regimens, One Failure Rate: Comparative Effectiveness of Pharmacotherapy for the Patent Ductus Arteriosus in Extremely Preterm Infants

Many babies born very early have an open blood vessel near the heart, called a patent ductus arteriosus, and doctors sometimes give medicine to close it. A Canadian study of 1356 babies born before 29 weeks found that four common treatment options (three medicines, one of them given at two doses)…

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Choosing Which Duct to Treat: Shunt-Volume Selection and the Redesign of Early PDA Trials in Extremely Preterm Infants
Randomized Clinical TrialEpidemiology & Biostatistics

Choosing Which Duct to Treat: Shunt-Volume Selection and the Redesign of Early PDA Trials in Extremely Preterm Infants

Many babies born extremely early have an open blood vessel near the heart, and doctors have long debated whether medicine to close it early helps. A small 2026 trial in babies born before 26 weeks used repeated heart scans to give medicine only to babies with a large blood flow; it showed a bigger…

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From Efficacy to Reach: Outpatient Simplified Antibiotics for Young Infants with Low-Mortality-Risk Possible Serious Bacterial Infection
Randomized Clinical TrialHealth Systems & Policy

From Efficacy to Reach: Outpatient Simplified Antibiotics for Young Infants with Low-Mortality-Risk Possible Serious Bacterial Infection

In poorer countries, babies under two months old with signs of a possible serious infection have long been sent to hospital for a week of injections. A study of 7001 babies in Africa and south Asia found that babies with just one milder warning sign did as well with two days of injections plus…

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Paid Family Leave as a Perinatal Exposure: Fewer Maternal Hypertensive Disorders and Infant Respiratory Encounters, With an Unresolved Signal in Birth Outcomes
Health Systems & PolicyEpidemiology & Biostatistics

Paid Family Leave as a Perinatal Exposure: Fewer Maternal Hypertensive Disorders and Infant Respiratory Encounters, With an Unresolved Signal in Birth Outcomes

New research from the United States suggests that when states give parents paid time off around the birth of a baby, fewer mothers develop high blood pressure in pregnancy and fewer very young babies need emergency care for breathing infections. One large study also found very small increases in…

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The Maternal Cost of Delivery Decisions at the Limit of Viability: A National Estimate of Morbidity After Periviable Cesarean Birth
Epidemiology & BiostatisticsEthics & Palliative Medicine

The Maternal Cost of Delivery Decisions at the Limit of Viability: A National Estimate of Morbidity After Periviable Cesarean Birth

When a baby is about to be born between 22 and 25 weeks of pregnancy, families often have to decide whether the birth should be by cesarean section (an operation through the belly and womb). A large US study of nearly 100 000 such births found that mothers who had a cesarean were more likely to…

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Discretion at the Bedside, Plans in the Statute Book: Hospital Reporting and State Policy for Infants With Prenatal Substance Exposure
Health Systems & PolicyEpidemiology & Biostatistics

Discretion at the Bedside, Plans in the Statute Book: Hospital Reporting and State Policy for Infants With Prenatal Substance Exposure

In Massachusetts and some other US states, babies exposed to opioids before birth were automatically reported to child protective services, even when the parent was taking prescribed treatment. When one Boston hospital reported only specific safety concerns, reports fell by about half, with no…

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Discharge Timing for Preterm Infants: Rising Discharge Age, Unit-Level Variation and the Evidence for Earlier Discharge with Home Support
Health Systems & PolicyEpidemiology & Biostatistics

Discharge Timing for Preterm Infants: Rising Discharge Age, Unit-Level Variation and the Evidence for Earlier Discharge with Home Support

Babies born very early are going home from hospital a few days later than they used to, and part of the reason seems to be how each hospital does things. A German hospital that taught parents early to tube-feed their babies sent many of them home about two weeks sooner, and those babies grew just…

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Survival, Disability and Whose Weights Count: Appraising the Evidence on How Parents, Clinicians and People Born Preterm Value Neonatal Outcomes
Ethics & Palliative MedicineMeta-analysis

Survival, Disability and Whose Weights Count: Appraising the Evidence on How Parents, Clinicians and People Born Preterm Value Neonatal Outcomes

When a baby is born very early, families and doctors sometimes have to weigh survival against the chance of lasting health problems. A 2026 review of 24 studies with more than 4,600 people found that parents and adults born preterm usually put survival first, while health professionals worried more…

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Procalcitonin-Guided Antibiotic Discontinuation in Neonatal Late-Onset Sepsis: Shorter Courses, Underpowered Safety Estimates
Randomized Clinical TrialMicrobiology

Procalcitonin-Guided Antibiotic Discontinuation in Neonatal Late-Onset Sepsis: Shorter Courses, Underpowered Safety Estimates

When a baby in neonatal intensive care develops an infection, antibiotics can be life-saving, but giving them for longer than needed can also cause harm. A large French study of 504 babies found that checking a blood marker called procalcitonin every two days helped doctors stop antibiotics about…

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