211 articles — showing all

Ranking Noninvasive Ventilation After Extubation: What a 23-Trial Network Meta-Analysis Says About NHFOV, NIPPV, BiPAP, and CPAP
Randomized Clinical TrialEpidemiology & Biostatistics

Ranking Noninvasive Ventilation After Extubation: What a 23-Trial Network Meta-Analysis Says About NHFOV, NIPPV, BiPAP, and CPAP

When a premature baby is ready to come off a breathing machine, the tube in the windpipe is removed and the baby is switched to a gentler form of support delivered through the nose. A large 2024 research review combined 23 clinical trials involving 2,331 newborns to compare four of these gentle…

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Does Early-Life Pain Leave a Lasting Trace? Pooled Evidence on Pain Sensitivity From Childhood to Adulthood After Preterm Birth
NeuroscienceEpidemiology & Biostatistics

Does Early-Life Pain Leave a Lasting Trace? Pooled Evidence on Pain Sensitivity From Childhood to Adulthood After Preterm Birth

Babies born too early often spend their first weeks in intensive care, where they experience many small painful procedures at a time when their nervous system is still developing. A 2026 research review gathered eight studies that tested how people born preterm feel pain years later — as children…

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Composite Fish-Oil Lipid Emulsion and Neonatal Morbidity: What Twenty Randomized Trials Reveal About SMOFlipid in Parenteral Nutrition
Nutrition & MetabolismEpidemiology & Biostatistics

Composite Fish-Oil Lipid Emulsion and Neonatal Morbidity: What Twenty Randomized Trials Reveal About SMOFlipid in Parenteral Nutrition

When a baby is born very early or too sick to feed by mouth, nutrition is given straight into a vein—a method called parenteral nutrition. A large review that combined 20 separate clinical trials, involving 1,904 newborns, found that one modern fat blend used in that intravenous feeding, called…

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One Strain or Three? School-Age Outcomes Do Not Distinguish Two Bifidobacterium Probiotics in Extremely Preterm Infants
Randomized Clinical TrialMicrobiology

One Strain or Three? School-Age Outcomes Do Not Distinguish Two Bifidobacterium Probiotics in Extremely Preterm Infants

When babies are born extremely early, many neonatal units give them a probiotic—friendly gut bacteria—to help protect their fragile intestines, and a long-running study has now checked whether the kind of probiotic makes any lasting difference. Researchers followed a group of children who, as tiny…

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Speed of Pulmonary Pressure Reduction Separates Two Oral Vasodilators in PPHN
PharmacologyRandomized Clinical Trial

Speed of Pulmonary Pressure Reduction Separates Two Oral Vasodilators in PPHN

Some newborns cannot get enough oxygen because the blood vessels in their lungs stay tightly closed after birth — a condition called persistent pulmonary hypertension of the newborn. The best treatment, a gas called inhaled nitric oxide, is unavailable in most hospitals worldwide. A trial in Pune…

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Does Early Sodium Supplementation Improve Growth in Very Preterm Infants? Two 2025–2026 Randomized Trials Reach Different Verdicts
Randomized Clinical TrialNutrition & Metabolism

Does Early Sodium Supplementation Improve Growth in Very Preterm Infants? Two 2025–2026 Randomized Trials Reach Different Verdicts

Premature babies often struggle to grow as quickly as they would have inside the womb, and doctors have long searched for safe ways to help. Two new clinical trials tested a simple, inexpensive idea: giving tiny babies a measured amount of extra salt (sodium). One trial found that extra salt helped…

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