37 articles in Respiratory

Antenatal Melatonin as an Adjunct to Corticosteroids for Neonatal Respiratory Distress: A Small Superiority Trial in Placenta Accreta Spectrum
Randomized Clinical TrialPharmacology

Antenatal Melatonin as an Adjunct to Corticosteroids for Neonatal Respiratory Distress: A Small Superiority Trial in Placenta Accreta Spectrum

A small study from Iran asked whether giving mothers melatonin — the natural hormone many people know as a sleep aid — in the two weeks before a planned early (premature) delivery could help their babies breathe more easily after birth. Every mother in the study also received the standard steroid…

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Nebulised Budesonide or Beclomethasone After the First Week of Life in Very Preterm Infants: A Randomised Trial of Respiratory Support Duration and Bronchopulmonary Dysplasia
Randomized Clinical TrialPharmacology

Nebulised Budesonide or Beclomethasone After the First Week of Life in Very Preterm Infants: A Randomised Trial of Respiratory Support Duration and Bronchopulmonary Dysplasia

For a very premature baby whose lungs are still developing, breathing support can go on for weeks, and many of these babies go on to develop a chronic lung condition called bronchopulmonary dysplasia, or BPD. A new study asked whether adding a breathed-in (inhaled) steroid medicine, given as a fine…

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Extending Permissive Hypercapnia Beyond the First Two Weeks: A Single-Centre Randomised Trial in Ventilator-Dependent Preterm Infants
Randomized Clinical TrialPhysiology

Extending Permissive Hypercapnia Beyond the First Two Weeks: A Single-Centre Randomised Trial in Ventilator-Dependent Preterm Infants

A 2025 study of 130 very premature babies who were still on a breathing machine at about two weeks of age found that allowing their blood carbon dioxide to sit a little higher than usual — while carefully keeping their blood chemistry within safe limits — helped them come off the machine sooner…

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Oscillation Without Advantage on Reintubation: A Head-to-Head Trial of Nasal High-Frequency Oscillation Versus Non-Synchronized NIPPV After Extubation
Randomized Clinical TrialPhysiology

Oscillation Without Advantage on Reintubation: A Head-to-Head Trial of Nasal High-Frequency Oscillation Versus Non-Synchronized NIPPV After Extubation

When a premature baby is well enough to come off a breathing machine, doctors still usually give gentle breathing help through the nose for a while. A new study compared two of those nasal methods in babies born about six to eight weeks early. Both kept the same number of babies from needing the…

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Leaving the Ventilator Connected: A Randomized Trial of Continued Non-Invasive Ventilation During Elective Neonatal Intubation
Randomized Clinical TrialPhysiology

Leaving the Ventilator Connected: A Randomized Trial of Continued Non-Invasive Ventilation During Elective Neonatal Intubation

When a premature baby in intensive care needs a breathing tube placed, doctors have traditionally removed the baby's nasal breathing support first — leaving the baby with no help at all for the twenty to forty seconds the procedure takes. A 2025 randomized trial in eastern India tested the obvious…

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