23 articles in Immunology & Infectious Diseases

A Measurable Microbial Signal Without a Measurable Clinical Consequence: Early Empiric Antibiotics, the Very Preterm Gut, and Late-Onset Sepsis
MicrobiologyMeta-analysis

A Measurable Microbial Signal Without a Measurable Clinical Consequence: Early Empiric Antibiotics, the Very Preterm Gut, and Late-Onset Sepsis

Most babies born very early receive antibiotics in their first hours, because a serious infection at birth is hard to rule out and dangerous to miss. Two new studies looked at what those antibiotics do. One found small, real changes in the mix of bacteria in the baby's gut. The other, much larger…

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Two Nomograms for Neonatal Sepsis: What a Single-Centre Chinese Cohort Can and Cannot Tell Us About Multivariable Diagnosis
Epidemiology & BiostatisticsMicrobiology

Two Nomograms for Neonatal Sepsis: What a Single-Centre Chinese Cohort Can and Cannot Tell Us About Multivariable Diagnosis

Doctors caring for newborns face a problem that has never had a clean solution: the early signs of a serious blood infection look almost exactly like the ordinary, harmless unsettledness of a baby in the first days of life. A team at a children's hospital in China has now built two scoring charts…

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Universal Nirsevimab and the Residual Burden of Prematurity and Household Exposure
PharmacologyEpidemiology & Biostatistics

Universal Nirsevimab and the Residual Burden of Prematurity and Household Exposure

A new antibody shot called nirsevimab, given to newborns before they leave the hospital, dramatically lowered the number of babies hospitalized with the winter virus RSV in a large real-world study from Italy. Across nearly 14,000 babies, hospital admissions for RSV lung infections dropped by about…

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One in 738, and Still an Underestimate: What a Statewide Dried Blood Spot Programme Reveals About the Limits of Screening for Congenital Cytomegalovirus
MicrobiologyEpidemiology & Biostatistics

One in 738, and Still an Underestimate: What a Statewide Dried Blood Spot Programme Reveals About the Limits of Screening for Congenital Cytomegalovirus

New York State spent a year adding one extra test to the routine heel-prick blood card that every newborn already receives, looking for a common virus called cytomegalovirus. Among just over 208,000 babies, the test found 276 who had been infected before birth — and more than half of the babies who…

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Gowns and Gloves in the NICU: The BALTIC Trial Challenges the Evidence Base for Extended Barrier Precautions Against 3rd-Generation Cephalosporin-Resistant Gram-Negative Bacteria
Randomized Clinical Trial

Gowns and Gloves in the NICU: The BALTIC Trial Challenges the Evidence Base for Extended Barrier Precautions Against 3rd-Generation Cephalosporin-Resistant Gram-Negative Bacteria

If your baby has been in a neonatal intensive care unit, you know the ritual. Before you can reach into the incubator, before you can lift your baby to your chest for skin-to-skin time, a nurse hands you a yellow gown — crinkly, too large, never quite fastening at the back — and sometimes a pair of…

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